Alloreactive T cells may recognize incompatible MHC molecules directly
on the stimulator antigen presenting cells (APC or dendritic cell) or indirectly
after processing by a responder or histocompatible stimulator APC. Usually, the APC migrates to lymph nodes where the
encounter with T cells occurs.
After activation, effector T cells recognize the incompatible molecules against which they have been primed and attack foreign tissues.
Recognition of incompatible tissue by T cells
Throughout the movies on allorecognition, proteins (MHC molecules as well as other polymorphic proteins of which the peptides are presented by the MHC-molecules) that differ between responder and stimulator will be depicted in red, while autologous proteins or proteins that are identical in the stimulator are depicted in blue.
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