Donor & CompatibilityCriteriaThe degree of HLA compatibility between donor and patient is crucial for the outcome of stem cell transplantation. Mismatched HLA-antigens represent important transplantation barriers. Other criteria are usually only taken into account when this influences the choice between two potential donors with the same HLA-compatibility. Read more... Compatibility testing (HLA typing)The degree of matching is determined by a series of histocompatibility tests referred to as HLA typing. Read more ... SearchThe chance of finding a histocompatible donor is by far the greatest within the family of the patient. Because the HLA-antigens are inherited in haplotypes, the chance that a patient is compatible with his sibling is 25%. If no suitable family donor is identified, a search for an unrelated donor can be performed in the international donor registries. Read more... Source of HSCOnce a suitable donor is found, the HSC can be harvested directly from the bone marrow or from the peripheral blood after the HSC have been recruited from the marrow by a treatment with G-CSF. Read more... HSC can be donated without a risk for the donor's health |
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Transplantation Immunology | |||||||||||||||||||
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