HSC transplantation, printed

Regeneration of innate components of the immune system

The number of granulocytes rises from day 10 and normalizes at the end of the first month. In most cases, the function of the granulocytes is normal and therefore, the number of granulocytes can be translated as protection against bacterial infections. The presence of more than 0.5 G/L neutrophils in the blood is considered as proof of engraftment. The number of NK cells normalizes during the first month after transplant. In general, the number of cells of the innate immune system correlates well with the function of the respective lineage. This does not hold for the adaptative immune system where the cells express different receptors and each individual T ot B cell may have another function. Here, the number of cells may be normal but when essential T or B cells are missing, the adaptive immune system may remain deficient.